Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?

@article{Thomas2006CouldBM,
  title={Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?},
  author={Nancy E. Thomas and Marianne Berwick and Marila Cordeiro-Stone},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 8},
  pages={1693-6}
}
Although BRAF V600 mutations in melanocytic tumors are not UV-signature mutations, it is plausible that they could still arise from error-prone replication of UV-damaged DNA. We propose a mechanism for their origin, taking into consideration melanocytic-specific BRAF tandem mutations, nearby potential pyrimidine dimer sites, the properties of specialized DNA polymerases, and biological selection. 

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