Cough pharmacotherapy: current and future status

@article{Gibson2011CoughPC,
  title={Cough pharmacotherapy: current and future status},
  author={Peter G. Gibson and Nicole M Ryan},
  journal={Expert Opinion on Pharmacotherapy},
  year={2011},
  volume={12},
  pages={1745 - 1755}
}
  • P. Gibson, N. Ryan
  • Published 8 July 2011
  • Medicine, Psychology
  • Expert Opinion on Pharmacotherapy
Introduction: Chronic cough is responsible for a significant illness burden in the community. Refractory cough causes substantial quality-of-life impairment in people with this problem. Neuromodulators for sensory neuropathic cough and new compounds to block transient receptor potential (TRP) receptors hold promise for chronic cough and upper airway hypersensitivity. Areas covered: The authors examine current evidence on the new concepts of chronic cough that relate to the study of idiopathic… 
Recent additions in the treatment of cough.
TLDR
Effective treatments for chronic cough target these areas and include behavioural treatment such as speech pathology and pharmaceutical treatment with neuromodulating medications such as gabapentin.
Gabapentin in chronic cough.
An update and systematic review on drug therapies for the treatment of refractory chronic cough
TLDR
A systematic review of drug therapies for refractory Chronic Cough found that repurposed pain medications such as gabapentin and pregabalin reduce the frequency of cough and improve quality of life and the P2X3 ion channel receptor antagonists show the most promise.
A review on the efficacy and safety of gabapentin in the treatment of chronic cough
  • N. Ryan
  • Medicine
    Expert opinion on pharmacotherapy
  • 2015
TLDR
Gabapentin appears to be effective and well tolerated in the treatment of CC and in other sensory neuropathic disorders and further studies are needed.
The use of neuralgia medications to treat sensory neuropathic cough: our experience in a retrospective cohort of thirty-two patients
TLDR
Amitriptyline, desipramine, and gabapentin appear to vary in their effectiveness for individual cases of sensory neuropathic cough; across a whole cohort, symptom relief was similar in frequency and degree on any of the three medications.
Upper Airway Cough Syndrome in Pathogenesis of Chronic Cough.
TLDR
The cough demonstrated by UACS patients is probably due to hypersensitivity of the upper airways sensory nerve or lower airway sensory nerve, or a combination of both, and further studies are needed to clarify this mechanism.
Revised Korean Cough Guidelines, 2020: Recommendations and Summary Statements
TLDR
Recommendations and summary of the revised Korean cough guidelines include a revised algorithm for the evaluation of acute, subacute, and chronic cough, which has been newly added to the guidelines.
The Korean Cough Guideline: Recommendation and Summary Statement
TLDR
Recommendation and summary of Korean cough guideline: If UACS is suspicious, first generation anti-histamine and nasal decongestant can be used empirically, and inhaled corticosteroid is recommended in order to improve cough.
Efficacy and Safety of Gabapentin in the Treatment of Chronic Cough: A Systematic Review
TLDR
Gabapentin treatment of patients with chronic cough showed superior efficacy and a good safety record compared with placebo or standard medications and additional randomized and controlled trials are needed.
Neurogenic cough
TLDR
Sensory neuropathy appears to be an important cause of chronic refractory cough, and appears amenable to treatment with a variety of pharmacologic agents.
...
1
2
3
4
...

References

SHOWING 1-10 OF 117 REFERENCES
Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers.
  • A. Vertigan, P. Gibson
  • Medicine, Psychology
    Journal of voice : official journal of the Voice Foundation
  • 2011
Sensory Neuropathic Cough: A Common and Treatable Cause of Chronic Cough
  • R. Bastian, A. Vaidya, K. Delsupehe
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2006
Opiate therapy in chronic cough.
TLDR
Morphine sulfate is an effective antitussive in intractable chronic cough at the doses of 5 to 10 mg twice daily in patients failing to respond to specific measures.
The Cough Hypersensitivity Syndrome: A Novel Paradigm for Understanding Cough
TLDR
The similarities between the different phenotypes far outweigh differences in a unifying diagnosis of the cough hypersensitivity syndrome, providing a more rational understanding of chronic cough.
The airway sensory hyperreactivity syndrome.
  • E. Millqvist
  • Medicine
    Pulmonary pharmacology & therapeutics
  • 2011
Chronic Cough as a Sign of Laryngeal Sensory Neuropathy: Diagnosis and Treatment
  • Bryant Lee, P. Woo
  • Medicine
    The Annals of otology, rhinology, and laryngology
  • 2005
TLDR
Patients identified as having sudden-onset cough, laryngospasm, or throat-clearing after viral illness, surgery, or an unknown trigger are presented and sensory neuropathy of the superior or recurrent laryngeal nerve is considered.
Assessment and measurement of cough: the value of new tools.
  • K. Chung
  • Medicine
    Pulmonary pharmacology & therapeutics
  • 2002
TLDR
Self-scoring evaluations are still widely used, but the inclusion of quality of life tools specifically adapted to the evaluation of cough appears to be a useful tool that can directly measure the impact of chronic cough.
An office approach to the diagnosis of chronic cough.
TLDR
By using a standard protocol for diagnosis and treatment, 90 percent of patients with chronic cough can be managed successfully in the family physician's office, however, in some cases it may take three to five months to determine a diagnosis and effective treatment.
Chronic idiopathic cough: a discrete clinical entity?
TLDR
Patients with CIC commonly describe a URTI that initiates their cough, which then lasts for many years, and they demonstrate an exquisitely sensitive cough reflex, suggesting that CIC may be a distinct clinical entity with an as-yet unidentified underlying pathology.
Gabapentin in the treatment of intractable idiopathic chronic cough: case reports.
...
1
2
3
4
5
...