Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction.

@article{Galan2001CotyledonAB,
  title={Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction.},
  author={Henry L. Galan and Timothy RH Regnault and Timothy D Le Cras and R. Weslie Tyson and Russell V Anthony and Randall B. Wilkening and Steven H Abman},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 6},
  pages={2420-6}
}
Heat exposure early in ovine pregnancy results in placental insufficiency and intrauterine growth restriction (PI-IUGR). We hypothesized that heat exposure in this model disrupts placental structure and reduces placental endothelial nitric oxide synthase (eNOS) protein expression. We measured eNOS protein content and performed immunohistochemistry for eNOS in placentas from thermoneutral (TN) and hyperthermic (HT) animals killed at midgestation (90 days). Placental histomorphometry was compared… CONTINUE READING