Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells.

@article{Guo2004CotreatmentWH,
  title={Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells.},
  author={Fei Yun Guo and Celia A. Sigua and Jianguo Tao and Purva Bali and Prince George and Yunqing Li and Sylvie Wittmann and Lynn C. Moscinski and Peter W Atadja and Kapil Bhalla},
  journal={Cancer research},
  year={2004},
  volume={64 7},
  pages={2580-9}
}
Present studies demonstrate that treatment with the histone deacetylases inhibitor LAQ824, a cinnamic acid hydroxamate, increased the acetylation of histones H3 and H4, as well as induced p21(WAF1) in the human T-cell acute leukemia Jurkat, B lymphoblast SKW 6.4, and acute myelogenous leukemia HL-60 cells. This was associated with increased accumulation of the cells in the G(1) phase of the cell cycle, as well as accompanied by the processing and activity of caspase-9 and -3, and apoptosis… CONTINUE READING
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