Cotreatment with dichloroacetate and omeprazole exhibits a synergistic antiproliferative effect on malignant tumors.

@article{Ishiguro2012CotreatmentWD,
  title={Cotreatment with dichloroacetate and omeprazole exhibits a synergistic antiproliferative effect on malignant tumors.},
  author={Tatsuaki Ishiguro and Miyu Ishiguro and Ryumei Ishiguro and Sayuri Iwai},
  journal={Oncology letters},
  year={2012},
  volume={3 3},
  pages={726-728}
}
It has been reported that treating cancer cells with dichloroacetate (DCA), an approved treatment for congenital lactic acidosis, reverses the Warburg effect and inhibits tumor growth). Furthermore, omeprazole (OMP) is a well-known agent that enhances the effects of anticancer drugs. The aim of this study was to find clinically-used drugs that enhance the effects of DCA. The combination of DCA and OMP exhibited a more potent antitumor activity than DCA alone in HT1080 fibrosarcoma cells and RKO… CONTINUE READING

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