Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients.

@article{Lazarus2005CotransplantationOH,
  title={Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients.},
  author={Hillard M Lazarus and Omer Nadir Koç and Steven Michael Devine and Peter Gardner Curtin and Richard T Maziarz and H. Kent Holland and Elizabeth J Shpall and Philip Mccarthy and Kerry M Atkinson and Brenda Wimpfheimer Cooper and Stanton L. Gerson and Mary J. Laughlin and Fausto R. Loberiza and Annemarie B Moseley and Andrea Bacigalupo},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2005},
  volume={11 5},
  pages={389-98}
}
Mesenchymal stem cells (MSCs) are found in a variety of tissues, including human bone marrow; secrete hematopoietic cytokines; support hematopoietic progenitors in vitro; and possess potent immunosuppressive properties. We hypothesized that cotransplantation of culture-expanded MSCs and hematopoietic stem cells (HSCs) from HLA-identical sibling donors after myeloablative therapy could facilitate engraftment and lessen graft-versus-host disease (GVHD); however, the safety and feasibility of this… CONTINUE READING
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