Cotransplantation of Cord Blood Hematopoietic Stem Cells and Culture-Expanded and GM-CSF-/SCF-Transfected Mesenchymal Stem Cells in SCID Mice

@inproceedings{Han2007CotransplantationOC,
  title={Cotransplantation of Cord Blood Hematopoietic Stem Cells and Culture-Expanded and GM-CSF-/SCF-Transfected Mesenchymal Stem Cells in SCID Mice},
  author={Jin Yeong Han and Rhee Young Goh and Su Yeong Seo and Tae Ho Hwang and Hyuk Chan Kwon and Sung-Hyun Kim and Jae Seok Kim and Hyo Jin Kim and Young Ho Lee},
  booktitle={Journal of Korean medical science},
  year={2007}
}
Mesenchymal stem cells (MSC) are multipotent in nature and believed to facilitate the engraftment of hematopoietic stem cells (HSC) when transplanted simultaneously in animal studies and even in human trials. In this study, we transfected culture-expanded MSC with granulocyte macrophage-colony stimulating factor (GMCSF) and stem cell factor (SCF) cytokine genes and then cotransplanted with mononuclear cells (MNC) to further promote HSC engraftment. MNC were harvested from cord blood and seeded… CONTINUE READING

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In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
In this study , we transfected culture - expanded MSC with granulocyte macrophage - colony stimulating factor ( GMCSF ) and stem cell factor ( SCF ) cytokine genes and then cotransplanted with mononuclear cells ( MNC ) to further promote HSC engraftment .
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