Cotranslational protein folding.

  title={Cotranslational protein folding.},
  author={Academician N. A. Fedorov and Thomas O. Baldwin},
  journal={The Journal of biological chemistry},
  volume={272 52},
The problem of how the linear amino acid sequence of a polypeptide folds to assume its unique tertiary structure is one of the most basic and challenging conundrums of contemporary science. Many of the principles and characteristics of protein folding have been learned by studying refolding of denatured polypeptides. However, the problem of protein folding cannot be completely understood without reference to the biological context of protein folding, especially for large, multidomain, and… CONTINUE READING