Cotranslational protein folding within the ribosome tunnel influences trigger-factor recruitment.

@article{Lin2012CotranslationalPF,
  title={Cotranslational protein folding within the ribosome tunnel influences trigger-factor recruitment.},
  author={Ku-Feng Lin and Chia-Sui Sun and Yi-Chen Huang and Sunney I Chan and Jiř{\'i} Koubek and T Wu and Joseph J-T Huang},
  journal={Biophysical journal},
  year={2012},
  volume={102 12},
  pages={
          2818-27
        }
}
In recent years, various folding zones within the ribosome tunnel have been identified and explored through x-ray, cryo-electron microscopy (cryo-EM), and molecular biology studies. Here, we generated ribosome-bound nascent polypeptide complexes (RNCs) with different polyalanine (poly-A) inserts or signal peptides from membrane/secretory proteins to explore the influence of nascent chain compaction in the Escherichia coli ribosome tunnel on chaperone recruitment. By employing time-resolved… CONTINUE READING
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