Cotranslational folding increases GFP folding yield.

@article{Ugrinov2010CotranslationalFI,
  title={Cotranslational folding increases GFP folding yield.},
  author={Krastyu G. Ugrinov and Patricia L. Clark},
  journal={Biophysical journal},
  year={2010},
  volume={98 7},
  pages={
          1312-20
        }
}
Protein sequences evolved to fold in cells, including cotranslational folding of nascent polypeptide chains during their synthesis by the ribosome. The vectorial (N- to C-terminal) nature of cotranslational folding constrains the conformations of the nascent polypeptide chain in a manner not experienced by full-length chains diluted out of denaturant. We are still discovering to what extent these constraints affect later, posttranslational folding events. Here we directly address whether… CONTINUE READING
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