Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex

@inproceedings{Conti2014CotranslationalFI,
  title={Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex},
  author={Brian J. Conti and Johannes Elferich and Zhongying Yang and Ujwal Shinde and William R. Skach},
  booktitle={Nature Structural &Molecular Biology},
  year={2014}
}
Eukaryotic secretory proteins cross the endoplasmic reticulum (ER) membrane through a protein-conducting channel contained within the ribosome–Sec61translocon complex (RTC). Using a zinc-finger sequence as a folding switch, we show that cotranslational folding of a secretory passenger inhibits translocation in canine ER microsomes and in human cells. Folding occurs within a cytosolically inaccessible environment, after ER targeting but before initiation of translocation, and it is most… CONTINUE READING
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