Cotransfection of HPV-18 and v-fos DNA induces tumorigenicity of primary human keratinocytes.

@article{Pei1993CotransfectionOH,
  title={Cotransfection of HPV-18 and v-fos DNA induces tumorigenicity of primary human keratinocytes.},
  author={Xu Fang Pei and Jeanne M. Meck and David Greenhalgh and Richard Schlegel},
  journal={Virology},
  year={1993},
  volume={196 2},
  pages={855-60}
}
Human keratinocytes were cotransfected with the FBJ/R v-fos oncogene and the HPV-18 genome and selected on the basis of their resistance to inducers of terminal differentiation. Unlike keratinocytes immortalized by HPV-18 DNA alone, the HPV-18/v-fos transformants exhibited prominent intracellular vacuolization and formed progressively growing, squamous cell… CONTINUE READING