Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses.

Abstract

BACKGROUND Cotransfection of dendritic cells (DC) with MART-1 and constitutively active TLR4 (caTLR4) RNA enhances the maturation of DC. MATERIALS AND METHODS Immature DC were cotransfected with RNA constructs encoding MART-1 and caTLR4, and CTL responses were analyzed. RESULTS Cotransfection of DC with MART-1 + caTLR4 enhanced the expression of CD80… (More)

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