Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.

@article{Fuchs2014CotranscriptionalHH,
  title={Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.},
  author={Gilad Fuchs and Dror Hollander and Yoav Voichek and Gil Ast and Moshe Oren},
  journal={Genome research},
  year={2014},
  volume={24 10},
  pages={1572-83}
}
Various histone modifications decorate nucleosomes within transcribed genes. Among these, monoubiquitylation of histone H2B (H2Bub1) and methylation of histone H3 on lysines 36 (H3K36me2/3) and 79 (H3K79me2/3) correlate positively with gene expression. By measuring the progression of the transcriptional machinery along genes within live cells, we now report that H2B monoubiquitylation occurs cotranscriptionally and accurately reflects the advance of RNA polymerase II (Pol II). In contrast… CONTINUE READING
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