Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines

  title={Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines},
  author={Sawalee Saosathan and Jalernsri Khounvong and Methee Rungrojsakul and Trinnakorn Katekunlaphan and Singkome Tima and Sawitree Chiampanichayakul and Cory J. Berkland and Songyot Anuchapreeda},
  journal={Natural Product Research},
  pages={988 - 992}
Abstract The magnolia plant has been used in traditional medicine since ancient times. This study was designed to investigate the effects of active compounds from Thai Champi Sirindhorn (Magnolia sirindhorniae) on leukemic biomarker Wilms’ tumor 1 (WT1) protein expressions in K562 and Molt-4 cells. Costunolide (1) and parthenolide (2) were the major components used in this study, they were purified from ethyl acetate fractions. Costunolide (1) and parthenolide (2) had strong cytotoxic effects… Expand
Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family.
This review systematically summarizes the antitumor activity and mechanism of COS and DEH in the recent reports, and discusses the effect of the key active part (α-methylene-γ-butyrolactone) of C OS andDEH against cancer. Expand
Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells
The results demonstrated that costunolide inhibited the viability of H1299 cells, with a half maximal inhibitory concentration value of 23.93±1.67 µM and induced cellular apoptosis in a dose-dependent manner, which indicates the potential of cost unolide in the treatment of NSCLC. Expand
Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer
  • Cuixiang Xu, Xiaoyan Huang, +9 authors Jianhua Wang
  • Frontiers in Cell and Developmental Biology
  • 2021
Objective: Costunolide (Cos) is a sesquiterpene lactone extracted from chicory. Although it possesses anti-tumor effects, the underlying molecular mechanism against gastric cancer cells remainsExpand


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Four sesquiterpene compounds with antileukemic activities against the KG1a and Molt4 cell lines were identified in Mah-Lueang extracts. Expand
Sesquiterpene lactones from the leaves of Magnolia sirindhorniae
Five sesquiterpene lactones, costunolide (1), santamarine (2), reynosin (3), parthenolide(4), and lipiferolides (5), were isolated from the leaves of Magnolia sirindhorniae by analysis of spectroscopic data and comparison with those reported in the literature. Expand
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
It is proposed that the activity of PTL triggers LSC-specific apoptosis and as such represents a potentially important new class of drugs for L SC-targeted therapy. Expand
Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.
Parthenolide may have potential as a potent and novel therapeutic agent against pre-B ALLs and was observed only in the two t(4;11) lines. Expand
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.
  • H. Sugiyama
  • Biology, Medicine
  • Japanese journal of clinical oncology
  • 2010
Findings suggest that a new era of WT1 immunotherapy is imminent, as WT1-specific cytotoxic T lymphocytes and WT1 antibodies are spontaneously induced in tumor-bearing patients, probably because of high immunogenicity of the WT1 protein. Expand
Co-activation of WT1 and AP-1 proteins on WT1 gene promoter to induce WT1 gene expression in K562 cells.
AP-1 contributes to the WT1 autoregulation of WT1 gene expression in leukaemic K562 cells in a dose-dependent manner as shown by immunoblotting. Expand
Inhibitory mechanism of pure curcumin on Wilms’ tumor 1 (WT1) gene expression through the PKCα signaling pathway in leukemic K562 cells
Ch Chromatin immunoprecipitation and reporter gene assays indicate that pure curcumin treatment attenuates WT1 auto‐regulation through inhibition of PKCα signaling in K562 cells. Expand
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