Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines

@article{Saosathan2019CostunolideAP,
  title={Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines},
  author={Sawalee Saosathan and Jalernsri Khounvong and Methee Rungrojsakul and Trinnakorn Katekunlaphan and Singkome Tima and Sawitree Chiampanichayakul and Cory J. Berkland and Songyot Anuchapreeda},
  journal={Natural Product Research},
  year={2019},
  volume={35},
  pages={988 - 992}
}
Abstract The magnolia plant has been used in traditional medicine since ancient times. This study was designed to investigate the effects of active compounds from Thai Champi Sirindhorn (Magnolia sirindhorniae) on leukemic biomarker Wilms’ tumor 1 (WT1) protein expressions in K562 and Molt-4 cells. Costunolide (1) and parthenolide (2) were the major components used in this study, they were purified from ethyl acetate fractions. Costunolide (1) and parthenolide (2) had strong cytotoxic effects… Expand
Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family.
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This review systematically summarizes the antitumor activity and mechanism of COS and DEH in the recent reports, and discusses the effect of the key active part (α-methylene-γ-butyrolactone) of C OS andDEH against cancer. Expand
Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells
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The results demonstrated that costunolide inhibited the viability of H1299 cells, with a half maximal inhibitory concentration value of 23.93±1.67 µM and induced cellular apoptosis in a dose-dependent manner, which indicates the potential of cost unolide in the treatment of NSCLC. Expand
Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer
  • Cuixiang Xu, Xiaoyan Huang, +9 authors Jianhua Wang
  • Frontiers in Cell and Developmental Biology
  • 2021
Objective: Costunolide (Cos) is a sesquiterpene lactone extracted from chicory. Although it possesses anti-tumor effects, the underlying molecular mechanism against gastric cancer cells remainsExpand

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