Corpus ID: 27218313

Costunolide Osteosarcoma cells Esophageal cancer cells Colon cancer cell Lung squamous carcinoma cells Breast cancer cells Prostate cancer cells Ovarian cancer cells

  title={Costunolide Osteosarcoma cells Esophageal cancer cells Colon cancer cell Lung squamous carcinoma cells Breast cancer cells Prostate cancer cells Ovarian cancer cells},
  author={Ana Flavia Burlec and Oana Cioancă and Luana Cătălina Enache and Monica Hăncianu},
PROMISING BIOLOGICAL ACTIVITIES OF SESQUITERPENE LACTONES (Abstract): Sesquiterpene lactones (SQLs) are an important group of bioactive compounds that are usually found in the Asteraceae family, where they seem to be some of the most important constituents for defense against microorganisms. These secondary metabolites have a skeleton of 15 carbon atoms and are derived from farnesyl diphosphate. It is generally believed that they might present certain biological actions in humans. Some of these… Expand

Tables from this paper


Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway
Insight is provided to understand the action of parthenolide as a potential B-Raf inhibitor in treatment of NSCLC and suppressed GLC-82 cell response via targeting on B- Raf and inhibiting MAPK/Erk pathway signaling. Expand
Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro
Interestingly, the melanoma cells from vertical growth phase and melanocytes were less susceptible to parthenolide-induced cell death than metastatic cells when drug concentration was at least 6 μmol/l, suggesting the reaction with intracellular thiols as the mechanism responsible for parthenolate activity. Expand
Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca‐109 Cells
It was found that costunolide inhibited the growth of Eca‐109 cells in a dose‐dependent manner, which was associated with the loss of mitochondrial membrane potential (Δψm) and the production of ROS. Expand
Parthenolide Induces Apoptosis and Cell Cycle Arrest of Human 5637 Bladder Cancer Cells In Vitro
It is suggested that parthenolide could be a novel therapeutic agent for treatment of bladder cancer. Expand
Alantolactone Induces Apoptosis and Cell Cycle Arrest on Lung Squamous Cancer SK‐MES‐1 Cells
The findings indicated that alantolactone has an antiproliferative role on lung squamous cancer cells, and it may be a promising chemotherapeutic agent for squamous lung cancer SK‐MES‐1 cells. Expand
Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species.
The apoptosis-inducing effect of costunolide, a natural sesquiterpene lactone, in platinum-resistant human ovarian cancer cells, along with the molecular mechanism of action are investigated to suggest that it may be of therapeutic potential in Platinum-resistant ovarian cancer. Expand
Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis
Investigating the effect and underlying mechanism of parthenolide in human pancreatic cancer and inhibiting autophagy by chloroquine, 3-methyladenine, or LC3II siRNA significantly blocked parthenlide-induced apoptosis suggest that parthensolide can serve as a potential chemotherapeutic agent for Pancic cancer. Expand
Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer
The administration of DMAPT in nude mice bearing xenografts of MDA-MB231 cells resulted in a significant inhibition of tumour growth, an increment of animal survival and a marked reduction of the lung area invaded by metastasis, suggesting a possible use of parthenolide for the treatment of TNBCs. Expand
Costunolide induces G1/S phase arrest and activates mitochondrial-mediated apoptotic pathways in SK-MES 1 human lung squamous carcinoma cells.
Flow cytometric analysis data demonstrated that costunolide significantly induced apoptosis of SK-MES-1 cells and induced cell cycle arrest at G1/S phase in a dose-dependent manner, and a significant loss of mitochondrial membrane potential indicated that cost unolide may induce apoptosis via the mitochondria-dependent pathway in SK- MES- 1 cells. Expand
A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells.
It is shown that costunolide exerts a dose-dependent antiproliferative activity in the human breast cancer MCF-7 cells, and light microscopy observations indicated that cost unolide affected nuclear organization and reorganized microtubule architecture, which may represent a new intracellular target for this drug. Expand