Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4+ T cells through the modulation of mitogen-activated protein kinases.

@article{Park2016CostunolideAS,
  title={Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4+ T cells through the modulation of mitogen-activated protein kinases.},
  author={Eunchong Park and Ju Han Song and Myun Soo Kim and Su-Ho Park and Tae Sung Kim},
  journal={International immunopharmacology},
  year={2016},
  volume={40},
  pages={
          508-516
        }
}
  • Eunchong Park, Ju Han Song, +2 authors Tae Sung Kim
  • Published in
    International…
    2016
  • Biology, Medicine
  • CD4+ T cell activation and adequate differentiation into effector T helper (Th) cells are crucial for mediating adaptive immune responses to cope with foreign pathogens. Despite the significant role of Th cells, excessive increases in their numbers result in inflammatory and autoimmune diseases. In this study, we investigated the effects of costunolide, a plant-derived natural compound with an anti-inflammatory activity, in regulating Th cells and the underlying mechanisms. Costunolide… CONTINUE READING

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