Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.

Abstract

The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphocytes from patients with MS, optic neuritis (ON) and other inflammatory central nervous system (CNS) diseases. In patients with ON but not MS, increased expression of B7-2 was detected as compared to non-inflammatory controls. The expression of B7-1 in MS and ON patients correlates with disease duration but not with relapses in patients with MS indicating a role in early disease but not as a reliable marker of disease activity at later stages of MS.

Cite this paper

@article{Windhagen1999CostimulatoryMB, title={Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.}, author={Anja Windhagen and Susanna Maniak and Andreas Gebert and I Ferger and Florian Heidenreich}, journal={Journal of neuroimmunology}, year={1999}, volume={96 1}, pages={112-20} }