Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules.

@article{Keller2007CostimulatoryLC,
  title={Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules.},
  author={Anna M. Keller and Tom Alphonsus Maria Groothuis and Elise A. M. Veraar and Marije Marsman and Lucas J. Maillette de Buy Wenniger and Hans – Gerd Janssen and Jacques Neefjes and Jannie Borst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 14},
  pages={
          5989-94
        }
}
TNF family member CD70 is the ligand of CD27, a costimulatory receptor that shapes effector and memory T cell pools. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). We show here that, in addition, specific intracellular routing controls its plasma membrane deposition. In professional antigen-presenting cells, such as DC, CD70 is sorted to late endocytic… CONTINUE READING
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