Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.

@article{Hancock1996CostimulatoryFA,
  title={Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.},
  author={Wayne W Hancock and Mohamed H. Sayegh and Xiang guang Zheng and Robert Peach and Peter S. Linsley and Lawrence A Turka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 24},
  pages={13967-72}
}
Recent data implicates a role for the CD40-CD40 ligand (CD40L) pathway in graft rejection. One potential mechanism is direct costimulation of T cells through CD40L. Alternatively, the ability of CD40 stimulation to induce CD80 (B7-1) and CD86 (B7-2) expression on antigen-presenting cells (APCs) has led to the hypothesis that the role of CD40-CD40L interactions in transplant rejection might be indirect, i.e., to promote the costimulatory capacity of APCs. Here, we have used a murine vascularized… CONTINUE READING

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