Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

@article{Tsuyuki1997CostimulationTB,
  title={Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness},
  author={Shogo Tsuyuki and J Tsuyuki and K Einsle and Manfred Kopf and Anthony J Coyle},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={1671 - 1680}
}
The recruitment of eosinophils into the airways after allergen exposure is dependent on interleukin (IL) 5 secreted from antigen-specific CD4+ T cells of the T helper cell (Th) 2 subset. However, while it is established that costimulation through CD28 is required for TCR-mediated activation and IL-2 production, the importance of this mechanism for the induction of a Th2 immune response is less clear. In the present study, we administered the fusion protein CTLA-4 immunoglobulin (Ig) into the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 99 CITATIONS, ESTIMATED 67% COVERAGE

Inhaled CD86 antisense oligonucleotide suppresses pulmonary inflammation and airway hyper-responsiveness in allergic mice.

  • The Journal of pharmacology and experimental therapeutics
  • 2007
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2002
VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Anti-CD86 (B7.2) treatment abolishes allergic airway hyperresponsiveness in mice.

  • American journal of respiratory and critical care medicine
  • 1999
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1998
2018

CITATION STATISTICS

  • 5 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

B7-2 (CD86) is essential for the development of IL-4 on July 7, 2017 em .rupss.org D ow nladed fom 1679

A. M. Ranger, M. P. Das, V. K. Kuchroo, L. H. Glimcher
  • Tsuyuki et al. producing T cells. Int. Immunol
  • 1996
VIEW 1 EXCERPT

Germinal centers in the lungs of mice following allergen provocation

Y. Chvatchko, M. Kosco-Vilbois, S. Herren, J. Lefort, J.-Y. Bonnefoy
  • J. Exp. Med
  • 1996
VIEW 1 EXCERPT

Differential effects of an anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

D. Lenscow, S. C. Ho, +5 authors J. A. Bluestone
  • J. Exp. Med. 181:1145–1155. on July 7,
  • 1995
VIEW 1 EXCERPT