Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.

@article{Wang2000CostimulationOT,
  title={Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.},
  author={Shengdian Wang and Gefeng Zhu and Andrei I. Chapoval and Haidong Dong and Koji Tamada and Jing Wei Ni and Lieping Chen},
  journal={Blood},
  year={2000},
  volume={96 8},
  pages={2808-13}
}
This report describes a new human B7-like gene designated B7-H2. Cell surface expression of B7-H2 protein is detected in monocyte-derived immature dendritic cells. Soluble B7-H2 and immunoglobulin (Ig) fusion protein, B7-H2Ig, binds activated but not resting T cells and the binding is abrogated by inducible costimulator Ig (ICOSIg), but not CTLA4Ig. In… CONTINUE READING