Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

@article{Reinhold1997CostimulationOT,
  title={Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway},
  author={Martina I. Reinhold and Frederik P. Lindberg and Gilbert J. Kersh and Paul E. Allen and Eric J. Brown},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={1 - 12}
}
The integrin-associated protein (IAP, CD47) is a 50-kD plasma membrane protein with a single extracellular immunoglobulin variable (IgV)-like domain, a multiply membrane-spanning segment, and alternatively spliced short cytoplasmic tails. On neutrophils, IAP has been shown to function in a signaling complex with beta 3 integrins. However, the function of IAP on T cells, which express little or no beta 3 integrin, is not yet defined. Here, we show that mAbs recognizing IAP can enhance… CONTINUE READING
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