Costimulation and autoimmune diabetes in BB rats.

  title={Costimulation and autoimmune diabetes in BB rats.},
  author={Britte C. Beaudette-Zlatanova and Barbara J. Whalen and Danny Zipris and H. Yagita and Jan Rozing and Herman Groen and Christopher D. Benjamin and Thomas Hunig and Hemmo A. Drexhage and Mohammed Javeed I. Ansari and Jean H. Leif and John P. Mordes and Dale L. Greiner and Mohamed H. Sayegh and Aldo A. Rossini},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={6 5 Pt 1},
Costimulatory signals regulate T-cell activation. To investigate the role of costimulation in autoimmunity and transplantation, we studied the BB rat model of type 1 diabetes. Diabetes-prone BB (BBDP) rats spontaneously develop disease when 55-120 days of age. We observed that two anti-CD28 monoclonal antibodies (mAb) with different functional activities completely prevented diabetes in BBDP rats. Anti-CD154 mAb delayed diabetes, whereas treatment with CTLA4-Ig or anti-CD80 mAb accelerated… CONTINUE READING


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