Costimulation Blockade in the Treatment of Rheumatic Diseases

@article{Liossis2012CostimulationBI,
  title={Costimulation Blockade in the Treatment of Rheumatic Diseases},
  author={Stamatis-Nick C. Liossis and Petros P. Sfikakis},
  journal={BioDrugs},
  year={2012},
  volume={18},
  pages={95-102}
}
The autoimmune response is executed via cognate interactions between effector immune cells and antigen presenting cells. Cognate interactions provide the immune effectors with specific signals generated through the antigen receptor as well as with second, non-specific signals, generated from the interaction of pairs of cell-surface molecules (costimulatory molecules) present on their plasma membrane. Disruption of this second, non-specific costimulatory signal results in the interruption of the… 
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