Costimulation, tolerance and ignorance of cytolytic T lymphocytes in immune responses to tumor antigens.

@article{Melero1997CostimulationTA,
  title={Costimulation, tolerance and ignorance of cytolytic T lymphocytes in immune responses to tumor antigens.},
  author={Ignacio Melero and Nancy Bach and Lan-ying Chen},
  journal={Life sciences},
  year={1997},
  volume={60 23},
  pages={2035-41}
}
Despite the fact that many tumors express MHC class I molecules presenting "foreign" peptide antigens, a vigorous tumor-destructing immune response is seldom detected. A possible explanation is that tumors cannot provide adequate costimulatory signals as provided by professional antigen presenting cells. CD28, upon interacting with B7, triggers costimulatory signals critical for the T-cell response. Transfection of tumor cells with B7 augments the immunogenicity of the tumor so that an anti… CONTINUE READING

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