Costal2 Functions as a Kinesin-like Protein in the Hedgehog Signal Transduction Pathway

@article{Farzan2008Costal2FA,
  title={Costal2 Functions as a Kinesin-like Protein in the Hedgehog Signal Transduction Pathway},
  author={Shohreh F. Farzan and Manuel Ascano and Stacey K Ogden and Matthieu Sanial and Amira Brigui and Anne Plessis and David J Robbins},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={1215-1220}
}
The Hedgehog (Hh) signaling pathway initiates an evolutionarily conserved developmental program required for the proper patterning of many tissues [1]. Although Costal2 (Cos2) is a requisite component of the Hh pathway, its mechanistic role is not well understood. Because of its primary sequence, Cos2 was initially predicted to function as a kinesin-like protein [2]. However, evidence showing that Cos2 function might require kinesin-like properties has been lacking [2-6]. Thus, the prevailing… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Bovine brain kinesin is a microtubule-activated ATPase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL