Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease.

@article{Guy2012CostainingFK,
  title={Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease.},
  author={Cynthia D. Guy and Ayako Suzuki and James L. Burchette and Elizabeth M. Brunt and Manal F. Abdelmalek and Diana Cardona and Shannon McCall and Aynur {\"U}nalp and Patricia A Belt and Linda D. Ferrell and Anna Mae Diehl},
  journal={Human pathology},
  year={2012},
  volume={43 6},
  pages={790-800}
}
Nonalcoholic fatty liver disease is a global health dilemma. The gold standard for diagnosis is liver biopsy. Ballooned hepatocytes are histologic manifestations of hepatocellular injury and are characteristic of steatohepatitis, the more severe form of nonalcoholic fatty liver disease. Definitive histologic identification of ballooned hepatocytes on routine stains, however, can be difficult. Immunohistochemical evidence for loss of the normal hepatocytic keratin 8/18 can serve as an objective… CONTINUE READING

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