Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis.

@article{Cotton2011CostutilityAO,
  title={Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis.},
  author={Bryan A. Cotton and Lillian S. Kao and Rosemary A. Kozar and John B. Holcomb},
  journal={The Journal of trauma},
  year={2011},
  volume={71 2},
  pages={375-9}
}
BACKGROUND The standard for early posttraumatic brain injury (TBI) seizure prophylaxis is phenytoin. Despite its effectiveness, some argue for the use of newer antiepileptics (e.g., levetiracetam) because phenytoin requires close monitoring to maintain its therapeutic window and is associated with rare cutaneous hypersensitivity reactions. The purpose of this study was to evaluate whether phenytoin or levetiracetam would be more cost-effective in preventing early post-TBI seizures and reducing… CONTINUE READING

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