Cost-effectiveness of transcranial magnetic stimulation in the treatment of major depression: a health economics analysis

@article{Simpson2009CosteffectivenessOT,
  title={Cost-effectiveness of transcranial magnetic stimulation in the treatment of major depression: a health economics analysis},
  author={Kit N. Simpson and Mary Jane Welch and F. Andrew Kozel and Mark A Demitrack and Ziad Nahas},
  journal={Advances in Therapy},
  year={2009},
  volume={26},
  pages={346-368}
}
IntroductionTranscranial magnetic stimulation (TMS) is a novel antidepressant therapy shown to be effective and safe in pharmacotherapy-resistant major depression. The incremental cost-effectiveness and the direct cost burden compared with sham treatment were estimated, and compared with the current standard of care.MethodsHealthcare resource utilization data were collected during a multicenter study (n=301) and a decision analysis was used to stratify the 9-week treatment outcomes. A Markov… 
Cost-Effectiveness of Repetitive Transcranial Magnetic Stimulation versus Antidepressant Therapy for Treatment-Resistant Depression.
  • K. Nguyen, L. Gordon
  • Psychology, Medicine
    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
  • 2015
Cost–Utility Analysis of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression in Ontario
TLDR
From a societal perspective utilizing a lifetime horizon, rTMS is a cost-effective first-line treatment option for TRD relative to ECT, as it is less expensive and produces better health outcomes.
Cost effectiveness analysis comparing repetitive transcranial magnetic stimulation to antidepressant medications after a first treatment failure for major depressive disorder in newly diagnosed patients – A lifetime analysis
TLDR
RTMS was identified as the dominant therapy compared to antidepressant medication trials over the life of the patient across the lifespan of adults with MDD, given current costs of treatment.
Economic evaluation of resistant major depressive disorder treatment in Iranian population: a comparison between repetitive Transcranial Magnetic Stimulation with electroconvulsive
TLDR
The sensitivity analysis showed that if the prevalence of major depressive disorders declines to below 5% or the costs of rT MS decrease (rTMS provided by public sector), then the rTMS becomes more cost-effective compared with ECT.
Cost-utility analysis of curative and maintenance repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant unipolar depression: a randomized controlled trial protocol
TLDR
In the case of significant decrease in the depression costs and expenditures associated with a good long-term prognosis (sustained response and remission) and tolerance, rTMS could be considered as an efficient treatment within the armamentarium for resistant unipolar depression.
Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability
TLDR
Although recent meta-analyses suggest sertraline and escitalopram might have increased efficacy/tolerability, other studies and large pragmatic trials have not found these to be superior to other antidepressant drugs and no superior drug was identified in terms of cost-effectiveness.
Transcranial magnetic stimulation for the treatment of major depression
TLDR
In the context of treating depression, a critically review the development of transcranial magnetic stimulation, focusing on the results of controlled and pragmatic trials for depression, which consider its efficacy, safety, and tolerability.
Repetitive transcranial magnetic stimulation treatment for peripartum depression: systematic review & meta-analysis
TLDR
In conclusion, repetitive transcranial magnetic stimulation can be considered an alternative treatment to treat peripartum depression to avoid exposure of fetuses to drugs and the severe side effects of electroconvulsive therapy.
A systematic literature review of the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in non-treatment resistant patients with major depressive disorder
TLDR
The use of rTMS in patients after ≤1 medication trial should be considered and US payers should consider revising their coverage policies to include the use of the device in these patients.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 42 REFERENCES
Decision Analysis of the Cost-Effectiveness of Repetitive Transcranial Magnetic Stimulation Versus Electroconvulsive Therapy for Treatment of Nonpsychotic Severe Depression
TLDR
Repetitive transcranial magnetic stimulation is a new treatment with promise for resistant depression and the economic feasibility of this new method compared with electroconvulsive therapy (ECT) was tested.
Transcranial magnetic stimulation in the acute treatment of major depressive disorder: clinical response in an open-label extension trial.
TLDR
This open-label study provides further evidence that TMS is a safe and effective treatment of major depressive disorder and provided additional benefit to some patients who failed to respond to 4 weeks of treatment, suggesting that longer courses of treatment may confer additional therapeutic benefit.
Transcranial magnetic stimulation in the treatment of major depressive disorder: a comprehensive summary of safety experience from acute exposure, extended exposure, and during reintroduction treatment.
TLDR
TMS was associated with a low incidence of adverse events that were mild to moderate in intensity and demonstrated a largely predictable time course of resolution, and may offer clinicians a novel, well-tolerated alternative for the treatment of major depressive disorder that can be safely administered in an outpatient setting.
Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: Clinical Predictors of Outcome in a Multisite, Randomized Controlled Clinical Trial
TLDR
The number of prior treatment failures was the strongest predictor for positive response to acute treatment with TMS, and shorter duration of current illness and lack of anxiety comorbidity may also confer an increased likelihood of good antidepressant response to TMS.
A randomized, controlled trial with 6-month follow-up of repetitive transcranial magnetic stimulation and electroconvulsive therapy for severe depression.
TLDR
Repetitive transcranial magnetic stimulation was not as effective as ECT, and ECT was substantially more effective for the short-term treatment of depression.
Clinical and cost-effectiveness of electroconvulsive therapy for depressive illness, schizophrenia, catatonia and mania: systematic reviews and economic modelling studies.
TLDR
Economic analysis may identify areas in which research would be best targeted by identifying parameters where reducing the level of uncertainty would have the most effect in helping to make the decision on whether ECT is a cost-effective treatment.
The Cognitive Effects of Electroconvulsive Therapy in Community Settings
TLDR
A prospective, naturalistic, longitudinal study of clinical and cognitive outcomes in patients with major depression treated at seven facilities in the New York City metropolitan area.
...
1
2
3
4
5
...