Cost-effectiveness of methods in personalized medicine. Results of a decision-analytic model in patients with acute myeloid leukemia with normal karyotype.

@article{Hrster2017CosteffectivenessOM,
  title={Cost-effectiveness of methods in personalized medicine. Results of a decision-analytic model in patients with acute myeloid leukemia with normal karyotype.},
  author={Laura H{\"o}rster and Richard F. Schlenk and Michael E. Stadler and Maria M. Gabriel and Felicitas Thol and Jan Schildmann and Jochen Vollmann and Ursula Rochau and Gaby Sroczynski and J{\"u}rgen Wasem and Arnold Ganser and Matthias Port and Anja Neumann},
  journal={Leukemia research},
  year={2017},
  volume={62},
  pages={
          84-90
        }
}

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References

SHOWING 1-10 OF 28 REFERENCES

Economic impact of genomic diagnostics for intermediate‐risk acute myeloid leukaemia

The results suggest that genomic analysis would result in a 26% increase in the use of first‐remission allogeneic stem cell transplantation, which would come at an additional cost of $12 556 per person and the incremental cost‐effectiveness ratio would be $49 493 per quality‐adjusted life‐year gained.

Personally Tailored Risk Prediction of AML Based on Comprehensive Genomic and Clinical Data

A novel prognostic framework based genomic sequencing data of 111 cancer genes matched with detailed diagnostic, treatment and survival data from 1,540 patients with AML enrolled in three different trials run by the German-Austrian AML Study Group is presented.

‘Acute myeloid leukemia: a comprehensive review and 2016 update'

The identification of recurrent genetic mutations, such as FLT3-ITD, NMP1 and CEBPA, has helped refine individual prognosis and guide management and here, the major recent advances in the treatment of AML are reviewed.

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Genetic predictors of outcome that improved risk stratification among patients with AML, independently of age, white-cell count, induction dose, and post-remission therapy, are identified and the significance of these predictors in an independent cohort is validated.

All-Trans Retinoic Acid Improves Outcome in Younger Adult Patients with Nucleophosmin-1 Mutated Acute Myeloid Leukemia – Results of the AMLSG 07-04 Randomized Treatment Trial

It is demonstrated that patients with mutated NPM1 and absence of a FLT3 internal tandem duplication (ITD) benefit from all- trans retinoic acid (ATRA) as adjunct to conventional chemotherapy in younger adult patients with AML.

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

Genotypes defined by the mutational status of NPM1, FLT3, CEBPA, MLL, and MLL are associated with the outcome of treatment for patients with cytogenetically normal AML.

Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics.

These gene mutations have emerged as important prognostic markers and they now allow us to dissect cytogenetically normal (CN)-AML in distinct prognostic subgroups, and these mutant molecules represent potential targets for molecular therapies.

Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials.

Compared with nonallogeneic SCT therapies, allogeneicSCT has significant RFS and overall survival benefit for intermediate- and poor-risk AML but not for good- risk AML in first complete remission.

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.

An international expert panel is provided to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials.

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation.

Multivariable analyses revealed a high allelic ratio as a predictive factor for the beneficial effect of allogeneic HSCT; ITD IS in TKD1 remained an unfavorable factor, whereas no prognostic impact of concurrent gene mutations was observed.