Cost-effectiveness of genetic testing in family members of patients with long-QT syndrome.

  title={Cost-effectiveness of genetic testing in family members of patients with long-QT syndrome.},
  author={Marco V Perez and Narmadan A Kumarasamy and Douglas K. Owens and Paul J Wang and Mark A. Hlatky},
  journal={Circulation. Cardiovascular quality and outcomes},
  volume={4 1},
BACKGROUND Family members of patients with established long-QT syndrome (LQTS) often lack definitive clinical findings, yet may have inherited an LQTS mutation and be at risk of sudden death. Genetic testing can identify mutations in 75% of patients with LQTS, but genetic testing of family members remains controversial. METHODS AND RESULTS We used a Markov model to assess the cost-effectiveness of 3 strategies for treating an asymptomatic 10-year-old, first-degree relative of a patient with… CONTINUE READING

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