Cost-effectiveness of combination daclatasvir-sofosbuvir for treatment of genotype 3 chronic hepatitis C infection in the United States

@article{Thibault2017CosteffectivenessOC,
  title={Cost-effectiveness of combination daclatasvir-sofosbuvir for treatment of genotype 3 chronic hepatitis C infection in the United States},
  author={Catherine Saint-Laurent Thibault and Divya Moorjaney and M. Ganz and B. Sill and S. Hede and Yong Yuan and B. Gorsh},
  journal={Journal of Medical Economics},
  year={2017},
  volume={20},
  pages={692 - 702}
}
Abstract Background: A phase III trial evaluated the efficacy and safety of Daklinza (daclatasvir or DCV) in combination with sofosbuvir (SOF) for treatment of genotype (GT) 3 hepatitis C virus (HCV) patients. Aim: This study evaluated the cost-effectiveness of DCV + SOF vs SOF in combination with ribavirin (RBV) over a 20-year time horizon from the perspective of a United States (US) payer. Methods: A published Markov model was adapted to reflect US demographic characteristics, treatment… Expand
12 Weeks of a Ribavirin‐Free Sofosbuvir and Nonstructural Protein 5A Inhibitor Regimen Is Enough to Treat Recurrence of Hepatitis C After Liver Transplantation
TLDR
SOF + NS5A inhibitors without RBV for 12 weeks constituted reliable therapy for recurrent HCV post‐LT with an excellent SVR12 whatever the fibrosis stage, HCV genotype, and previous HCV treatment. Expand
Re: Saint-Laurent Thibault C, Moorjaney D, Ganz ML, et al. Cost-effectiveness of combination daclatasvir-sofosbuvir for treatment of genotype 3 chronic hepatitis C infection in the United States. J Med Econ 2017;20:692-702
TLDR
A thorough review of the model assumptions and model parameters indicates that the relative cost-effectiveness of DCVþ SOF may have been over-estimated, and if data for adherence, relapse, transition probabilities, relevant comparators, and additional population characteristics were considered, more precise cost effectiveness could be obtained. Expand
Reply: Cost-effectiveness of combination daclatasvir-sofosbuvir for treatment of genotype 3 chronic hepatitis C infection in the United States
TLDR
The baseline distribution of fibrosis and cirrhosis stages that were used, and that are presented in Table 1 of this paper, came from the McGarry et al. article (for all ages). Expand
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The article provides a foundation of evidence that hepatitis C virus treatment provides good economic value, even though it is expensive, and even when treating people who inject drugs who are at high risk for hepatitis Cirus reinfection. Expand
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The model-based evidence suggests that a properly constructed strategy that substantially expands HCV treatment could achieve cost-effective improvements in population health in many countries. Expand
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In vivo results showed that Sofosbuvir availability in the liver was significantly increased after oral administration of the plain and the galactosylated bilosomal formulae when compared to the oral drug solution with relative targeting efficiencies of 1.51 and 3.66, respectively. Expand

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