Cost-effectiveness Analysis of CYP2D6*10 Pharmacogenetic Testing to Guide the Adjuvant Endocrine Therapy for Postmenopausal Women with Estrogen Receptor Positive Early Breast Cancer in China

@article{Wei2019CosteffectivenessAO,
  title={Cost-effectiveness Analysis of CYP2D6*10 Pharmacogenetic Testing to Guide the Adjuvant Endocrine Therapy for Postmenopausal Women with Estrogen Receptor Positive Early Breast Cancer in China},
  author={X. Wei and H. Sun and J. Zhuang and Xiuhua Weng and Bin Zheng and Qiwang Lin and Guifeng Zhang and Jiaqin Cai},
  journal={Clinical Drug Investigation},
  year={2019},
  volume={40},
  pages={25 - 32}
}
  • X. Wei, H. Sun, +5 authors Jiaqin Cai
  • Published 2019
  • Medicine
  • Clinical Drug Investigation
  • A CYP2D6 gene polymorphism is related to the effect of tamoxifen treatment in patient with estrogen-receptor positive (ER) positive breast cancer and CYP2D6*10 T/T can lead to a poor prognosis in Asian patients. Although one-off pharmacogenetic testing may optimize adjuvant endocrine therapy, testing prior to tamoxifen initiation incurs additional costs. We conducted a study to assess the cost-effectiveness of CYP2D6*10 pharmacogenetic testing to guide the adjuvant endocrine therapy compared… CONTINUE READING
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