Cost-effective G-CSF therapy strategies for cyclical neutropenia: mathematical modelling based hypotheses.

@article{Foley2006CosteffectiveGT,
  title={Cost-effective G-CSF therapy strategies for cyclical neutropenia: mathematical modelling based hypotheses.},
  author={Catherine Foley and Samuel Bernard and Michael C. Mackey},
  journal={Journal of theoretical biology},
  year={2006},
  volume={238 4},
  pages={754-63}
}
Using computer simulations of a mathematical model for the regulation of stem cell and neutrophil production in dogs, we have studied the efficacy of four different treatment protocols for cyclical neutropenia involving granulocyte colony stimulating factor (G-CSF). The first treatment scheme is based on the bifurcation analysis of the mathematical model and proposes a daily, phase-dependent, protocol. The second involves alternate day administration of G-CSF. The third triggers G-CSF… CONTINUE READING
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