Cost-benefit analysis of targeted ultrasonography for prenatal detection of spina bifida in patients with an elevated concentration of second-trimester maternal serum alpha-fetoprotein.

@article{Vintzileos1999CostbenefitAO,
  title={Cost-benefit analysis of targeted ultrasonography for prenatal detection of spina bifida in patients with an elevated concentration of second-trimester maternal serum alpha-fetoprotein.},
  author={Anthony M. Vintzileos and Cande V Ananth and Allan J Fisher and John C. Smulian and Debra L Day-Salvatore and Tryfon J. Beazoglou and Robert A. Knuppel},
  journal={American journal of obstetrics and gynecology},
  year={1999},
  volume={180 5},
  pages={1227-33}
}
OBJECTIVE The objectives of this study were to examine (1) the diagnostic accuracy requirements (from the cost-benefit point of view) of targeted ultrasonography versus genetic amniocentesis for prenatal detection of spina bifida in women with an elevated level of maternal serum alpha-fetoprotein, (2) the ultrasonographic accuracy of previously published… CONTINUE READING