Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal

  title={Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal},
  author={Phillip Oliver Coffin and Sean D. Sullivan},
  journal={Annals of Internal Medicine},
  pages={1 - 9}
BACKGROUND Opioid overdose is a leading cause of accidental death in the United States. OBJECTIVE To estimate the cost-effectiveness of distributing naloxone, an opioid antagonist, to heroin users for use at witnessed overdoses. DESIGN Integrated Markov and decision analytic model using deterministic and probabilistic analyses and incorporating recurrent overdoses and a secondary analysis assuming heroin users are a net cost to society. DATA SOURCES Published literature calibrated to… 

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