Cost-Effectiveness of Biological Asthma Treatments: A Systematic Review and Recommendations for Future Economic Evaluations

@article{McQueen2018CostEffectivenessOB,
  title={Cost-Effectiveness of Biological Asthma Treatments: A Systematic Review and Recommendations for Future Economic Evaluations},
  author={R. Brett McQueen and Danielle N. Sheehan and Melanie D. Whittington and Job Fm Van Boven and Jonathan D. Campbell},
  journal={PharmacoEconomics},
  year={2018},
  volume={36},
  pages={957-971}
}
BackgroundRecently developed asthma biological therapies have been shown to provide relief for severe asthma patients not controlled by inhaled treatment. Given the relatively high costs of biological therapies, cost-effectiveness analyses (CEAs) may be required as a prerequisite for coverage and reimbursement.ObjectiveWe aimed to systematically review published literature on the economic impact of biological asthma therapies and to identify key drivers that impact cost-effectiveness in order… 

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References

SHOWING 1-10 OF 66 REFERENCES

Optimizing the position and use of omalizumab for severe persistent allergic asthma using cost-effectiveness analysis.

  • R. FariaC. McKennaS. Palmer
  • Medicine, Political Science
    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
  • 2014

Cost-Effectiveness Analysis of Omalizumab for the Treatment of Severe Persistent Asthma in Real Clinical Practice in Spain

TLDR
The results of this study confirm the effectiveness of the addition of omalizumab to standard therapy in patients with uncontrolled severe persistent asthma.

Cost-effectiveness of omalizumab for uncontrolled allergic asthma in the Netherlands

TLDR
Non-clinical trial experience with omalizumab supported the finding of fewer exacerbations in the allergic asthma population while treated with o malzumab, and therapy was found to continue to have an attractive cost-effectiveness ratio.

Cost-effectiveness of tiotropium versus omalizumab for uncontrolled allergic asthma in US

TLDR
Add-on therapy with tiotropium was a cost-effective alternative to omalizumab and standard therapy for uncontrolled allergic asthma at willingness-to-pay of $50,000/QALY.

Cost-effectiveness of omalizumab in severe persistent asthma in Spain: a real-life perspective

TLDR
Adding omalizumab to the treatment of patients with uncontrolled severe persistent asthma reduces the number of exacerbations with ER visits and increases health-related quality of life after 10 months of treatment and produces ICERs favorable to omalzumab and acceptable from the health system perspective.

Assessing the value of mepolizumab for severe eosinophilic asthma: a cost-effectiveness analysis.

Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma.

Real-world health care utilization and effectiveness of omalizumab for the treatment of severe asthma.

  • Mina TadrousW. Khuu T. Gomes
  • Medicine, Political Science
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2018

Asthma outcomes: healthcare utilization and costs.

...