Cost Comparison of Parenteral Estrogen and Conventional Hormonal Treatment in Patients With Prostatic Cancer

@article{Henriksson1991CostCO,
  title={Cost Comparison of Parenteral Estrogen and Conventional Hormonal Treatment in Patients With Prostatic Cancer},
  author={Peter Henriksson and Reinhard Stege},
  journal={International Journal of Technology Assessment in Health Care},
  year={1991},
  volume={7},
  pages={220 - 226}
}
  • P. HenrikssonR. Stege
  • Published 1 March 1991
  • Medicine, Biology
  • International Journal of Technology Assessment in Health Care
Abstract The present study compares the cost of antitumor therapy and adverse cardiovascular effects during the first year of treatment with oral estrogens, nonoral estrogens, or surgical castration in patients with prostatic cancer. We found a much higher cost for patients treated with orchidectomy and oral estrogens than for patients treated with nonoral estrogens. Twenty-five percent of the patients treated with oral estrogen suffered cardiovascular complications, compared to none of the… 
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10 Citations

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The magnitude of these diseases, therapies available and relevant cost-effectiveness studies are reviewed, and each therapeutic method has its advocates, and overall survival rates are similar for all treatments.

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Quality of life, sexual functioning and sex role identity after surgical orchidectomy in patients with prostatic cancer.

Investigation of quality of life, sex-role identity, and sexual function in 15 patients with stage D prostate cancer, before and after surgery found orchidectomy did not appear to affect quality ofLife, or sex- role identity, however, loss of sexual function did present as an area of concern.

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Geographic Variation in the Treatment of Prostate Cancer in Connecticut

  • A. Polednak
  • Medicine
    International Journal of Technology Assessment in Health Care
  • 1993
Abstract In Connecticut there was considerable variation by town of residence in the proportions of patients diagnosed in 1985–1988 receiving transurethral resection only, prostatectomy, and…

Sensitivity Analysis in Health Economic and Pharmacoeconomic Studies

Improvement is required in the extent of reporting of sensitivity analyses in the health economics despite the fact that all published pharmacoeconomic guidelines suggest the use of sensitivity analysis.

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References

SHOWING 1-10 OF 20 REFERENCES

Cost-Effectiveness Comparison of Estrogen Therapy and Orchidectomy in Patients With Prostatic Cancer

The fact that 25% of the patients treated with estrogen suffered cardiovascular complications, but no difference in mortality rates between the two groups was observed, speaks in favor of orchidectomy as the preferred treatment for prostatic carcinoma.

Estrogen treatment for cancer of the prostate. Early results with 3 doses of diethylstilbestrol and placebo

The 1.0-mg dose has been as effective as the 5.0‐mg dose in controlling the prostate cancer, but it does not seem to be associated with the excess risk of cardiovascular death.

Cardiovascular complications to treatment of prostate cancer with estramustine phosphate (Estracyt) or conventional estrogen. A follow-up of 212 randomized patients.

Cardiovascular complications categorized as impaired arterial circulation including ischemic heart disease, venous thromboembolism, cardiac incompensation and cerebral depression were found to be equally frequent following the two different forms of treatment.

Cardiovascular follow‐up of patients with prostatic cancer treated with single‐drug polyestradiol phosphate

Patients with cancer of the prostate treated with strict parenteral estrogen in the form of monthly polyestradiol phosphate injections have responded to therapy and there have been no cardiovascular complications at a mean follow‐up of 12.9 ± 0.7 months.

Single‐drug parenteral estrogen treatment in prostatic cancer: A study of two maintenance‐dose regimens

Treatment of 17 patients with prostatic cancer with 320 mg polyestradiol phosphate (PEP) as intramuscular injections every fourth week suppressed serum testosterone (T) values to orchidectomy levels…

Effect of parenteral oestrogen on the coagulation system in patients with prostatic carcinoma.

Parenteral administration of oestrogen caused a less marked change in the coagulation system than oral administration and should be the treatment of choice for prostatic carcinoma.

Estrogen therapy and liver function—metabolic effects of oral and parenteral administration

Oral estrogen therapy for prostatic cancer is clinically effective but also accompanied by severe cardiovascular side effects, and the impact of exogenous estrogens on the liver is dependent on the route of administration and the type and dose of estrogen.

STUDIES ON PROSTATIC CANCER: II. THE EFFECTS OF CASTRATION ON ADVANCED CARCINOMA OF THE PROSTATE GLAND

Evidence is presented that significant improvement often occurs in the clinical condition of patients with far advanced cancer of the prostate after they have been subjected to castration and this work provides a new concept of prostatic carcinoma.

Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate

It is demonstrated that a marked rise in acid phosphatase in serum is associated with the appearance or spread of roentgenologically demonstrable skeletal metastases and implies dissemination of the primary tumor and thus is of unfavorable prognostic significance.

Activators and inhibitors of coagulation and fibrinolysis in patients with prostatic cancer treated with oestrogen or orchidectomy.