Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis

@article{Niethammer2002CosignalingON,
  title={Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis},
  author={Philipp Niethammer and Markus Delling and Vladimir Sytnyk and Alexander E. Dityatev and Kiyoko Fukami and Melitta Schachner},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={521 - 532}
}
The neural cell adhesion molecule (NCAM) has been reported to stimulate neuritogenesis either via nonreceptor tyrosine kinases or fibroblast growth factor (FGF) receptor. Here we show that lipid raft association of NCAM is crucial for activation of the nonreceptor tyrosine kinase pathway and induction of neurite outgrowth. Transfection of hippocampal neurons of NCAM-deficient mice revealed that of the three major NCAM isoforms only NCAM140 can act as a homophilic receptor that induces neurite… CONTINUE READING

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