Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure.

@article{Kurtz1990CosegregationOT,
  title={Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure.},
  author={Theodore W. Kurtz and Lizette Simonet and Pokar M. Kabra and Susan Wolfe and Laurence K. Chan and Brian L. Hjelle},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={85 4},
  pages={1328-32}
}
The spontaneously hypertensive rat (SHR) exhibits alterations in the renin-angiotensin-aldosterone system which are similar to those that characterize patients with "nonmodulating" hypertension, a common and highly heritable form of essential hypertension. Accordingly, we determined whether the inheritance of a DNA restriction fragment length polymorphism (RFLP) marking the renin gene of the SHR was associated with greater blood pressure than inheritance of a RFLP marking the renin gene of a… CONTINUE READING
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