Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties.

@article{Marino2009CoscinolactamsAA,
  title={Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties.},
  author={S. Marino and Carmen Festa and M. V. D'Auria and M. Bourguet‐Kondracki and S. Petek and C. Debitus and R. M. Andr{\'e}s and M. Terencio and M. Payá and A. Zampella},
  journal={Tetrahedron},
  year={2009},
  volume={65},
  pages={2905-2909}
}
Abstract Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with known suvanine. The structures were elucidated by extensive spectroscopic measurements including NOE experiments to deduce the stereochemistry. The natural compounds, as well as a semisynthetic derivative, showed moderate anti-inflammatory activity measured as their capability to inhibit PGE2 and NO… Expand
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