Corynebacterium glutamicum tailored for high-yield L-valine production


We recently engineered the wild type of Corynebacterium glutamicum for the growth-decoupled production of L-valine from glucose by inactivation of the pyruvate dehydrogenase complex and additional overexpression of the ilvBNCE genes, encoding the L-valine biosynthetic enzymes acetohydroxyacid synthase, isomeroreductase, and transaminase B. Based on the… (More)
DOI: 10.1007/s00253-008-1444-z


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@article{Blombach2008CorynebacteriumGT, title={Corynebacterium glutamicum tailored for high-yield L-valine production}, author={Bastian Blombach and M. E. Schreiner and Tobias Bartek and Marco Oldiges and Bernhard J. Eikmanns}, journal={Applied Microbiology and Biotechnology}, year={2008}, volume={79}, pages={471-479} }