Corynebacterium glutamicum Methionine Sulfoxide Reductase A Uses both Mycoredoxin and Thioredoxin for Regeneration and Oxidative Stress Resistance

  title={Corynebacterium glutamicum Methionine Sulfoxide Reductase A Uses both Mycoredoxin and Thioredoxin for Regeneration and Oxidative Stress Resistance},
  author={Meiru Si and Lei Zhang and Muhammad Tausif Chaudhry and Wei Ding and Yixiang Xu and Can Chen and Ali Ebadi Akbar and Xihui Shen and Shuangjiang Liu},
  journal={Applied and Environmental Microbiology},
  pages={2781 - 2796}
ABSTRACT Oxidation of methionine leads to the formation of the S and R diastereomers of methionine sulfoxide (MetO), which can be reversed by the actions of two structurally unrelated classes of methionine sulfoxide reductase (Msr), MsrA and MsrB, respectively. Although MsrAs have long been demonstrated in numerous bacteria, their physiological and biochemical functions remain largely unknown in Actinomycetes. Here, we report that a Corynebacterium glutamicum methionine sulfoxide reductase A… 

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