Cortistatin promotes and negatively correlates with slow-wave sleep.

  title={Cortistatin promotes and negatively correlates with slow-wave sleep.},
  author={Patrice Bourgin and V{\'e}ronique Fabre and Salvador Huitr{\'o}n-Res{\'e}ndiz and Steven J. Henriksen and O Prosp{\'e}ro-garc{\'i}a and Jos{\'e} Ramon Criado and Luis de Lecea},
  journal={The European journal of neuroscience},
  volume={26 3},
Sleep need is characterized by the level of slow-wave activity (SWA) and increases with time spent awake. The molecular nature of this sleep homeostatic process is practically unknown. Here, we show that intracerebroventricular administration of the neuropeptide, cortistatin (CST-14), enhances EEG synchronization by selectively promoting deep slow-wave sleep (SWS) during both the light and dark period in rats. CST-14 also increases the level of slow-wave activity (SWA) within deep SWS during… CONTINUE READING

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