Cortisol treatment affects glucocorticoid receptor and glucocorticoid-responsive genes in the liver of rainbow trout.

@article{Vijayan2003CortisolTA,
  title={Cortisol treatment affects glucocorticoid receptor and glucocorticoid-responsive genes in the liver of rainbow trout.},
  author={Mathilakath M Vijayan and Stavroula R Raptis and Ramesh Sathiyaa},
  journal={General and comparative endocrinology},
  year={2003},
  volume={132 2},
  pages={256-63}
}
We investigated whether longer-term cortisol exposure modified hepatic glucocorticoid receptor (GR) status and tissue responsiveness to cortisol stimulation in rainbow trout. Fish were given intraperitoneal implants of cortisol (50mg/kg body mass) and this led to elevated plasma cortisol levels mimicking chronically stressed salmonids. There was significantly higher hepatic GR mRNA abundance, despite a drop in GR protein content in the liver of cortisol-treated fish. The tissue responsiveness… CONTINUE READING

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