Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study

@article{Noordam2012CortisolSL,
  title={Cortisol serum levels in familial longevity and perceived age: The Leiden Longevity Study},
  author={Raymond Noordam and David A. Gunn and Cyrena C. Tomlin and Maarten Pieter Rozing and Andrea Britta Maier and Pieternella E Slagboom and Rudi G. J. Westendorp and Diana van Heemst and A.J.M. de Craen},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37},
  pages={1669-1675}
}
BACKGROUND Cortisol levels are strongly associated with a person's health. Familial longevity and age assessment of facial photographs (perceived age) are both associated with morbidity and mortality. The present study aimed to investigate morning cortisol levels in familial longevity and the association of these levels with perceived age. METHODS Perceived age and serum morning cortisol levels were measured for 138 offspring from long-lived families and 138 partners from the Leiden Longevity… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Perceived age as clinically useful biomarker of ageing: cohort study
TLDR
Perceived age—which is widely used by clinicians as a general indication of a patient’s health—is a robust biomarker of ageing that predicts survival among those aged ≥70 and correlates with important functional and molecular ageing phenotypes. Expand
Influence of environmental factors on facial ageing.
TLDR
This study confirms previous findings of a negative influence of sun exposure, smoking and a low BMI on facial ageing and indicates that high social status, low depression score and being married are associated with a younger look, but the strength of the associations varies between genders. Expand
Increased glucocorticoid activity in men with cardiovascular risk factors.
TLDR
In young men with higher blood pressure whose parents also had high blood pressure, enhanced glucocorticoid sensitivity was accompanied by enhanced secretion of cortisol, enhanced ligand-binding affinities for dexamethasone in leukocytes, and impaired conversion of cortisol to inactive metabolites (cortisone and 5beta-dihydrocortisol). Expand
Chronic psychosocial stress predicts long-term cardiovascular morbidity and mortality in middle-aged men.
TLDR
Self-reported chronic stress is an independent risk factor for CVD, particularly fatal stroke, in middle-aged men; it continues to be a risk factor after adjustment for several other known risk factors. Expand
Neuroendocrine features in extreme longevity
TLDR
It is suggested that the circadian rhythm of melatonin secretion is maintained in centenarians and, based on the limitations of this study, could be considered one factor in successful aging. Expand
Chronic stress and mortality among older adults.
TLDR
The article by Schulz and Beach in this issue of The Journal is the first study to demonstrate that caregiving is a risk factor for mortality, and thus it makes an important contribution to the broader literature on chronic stress. Expand
Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination
TLDR
Elderly carers of spouses with dementia have increased activation of the hypothalamic-pituitary-adrenal axis and a poor antibody response to influenza vaccine, and carers may be more vulnerable to infectious disease than the population of a similar age. Expand
Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study
TLDR
It is concluded that the sample is genetically enriched for extreme survival, because the spouses of the long-living participants had a mortality risk comparable with the general Dutch population, whereas they share the same environment. Expand
Obesity and cortisol.
TLDR
The results suggest that the pattern of cortisol secretion may be important and that programming of the hypothalamic-pituitary-adrenal axis may be responsible for the abnormal metabolism often seen in central obesity. Expand
Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression
TLDR
The cortisol-induced increase in serotonin uptake in lymphocytes from hypercortisolemic patients, including subjects with major depressive disorder and subjects with generalized anxiety disorder is investigated, in comparison with a control group of normal healthy subjects. Expand
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