Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) isoforms.

@article{Hough2013CortisolPI,
  title={Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17$\alpha$-hydroxylase/17,20-lyase (CYP17) isoforms.},
  author={Denise Hough and Schalk W.P. Cloete and Karl-Heinz Storbeck and Amanda C. Swart and Pieter Swart},
  journal={Journal of animal science},
  year={2013},
  volume={91 3},
  pages={
          1193-206
        }
}
In commercial production systems, the full expression of the genetic potential of an animal is limited by its intrinsic and extrinsic environment. It is therefore necessary to include robustness as a breeding goal because robustness is defined as the ability of an animal to express a high production potential in a wide variety of environmental conditions. The ability of mammals to produce sufficient cortisol on stimulation of the hypothalamic-pituitary-adrenal (HPA) axis is vital in its… 
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References

SHOWING 1-10 OF 32 REFERENCES
Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications.
TLDR
Using NADPH-cytochrome P-450 reductase as electron donor the homogeneous pig CYP17 was shown to catalyse the conversion of delta 5, as well as delta 4, steroids (pregnenolone and progesterone respectively) predominantly into the corresponding 17 alpha-hydroxylated products.
Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species.
TLDR
Differences in biochemical properties between the two forms of P450c17 indicate that human P 450c17 has evolved as an enzyme system that limits androgen production to the gonads where a favorable b5:P450c 17 ratio exists.
Impact of differential P450c17 phosphorylation by cAMP stimulation and by starvation conditions on enzyme activities and androgen production in NCI-H295R cells.
TLDR
It is concluded that serum withdrawal shifts steroidogenesis of H295R cells towards androgen production, providing a suitable model for detailed studies of androgen regulation and shows that starvation and cAMP stimulation regulate P 450c17 phosphorylation differentially and that an increase in P450c17osphorylation does not necessarily lead to enhanced enzyme activity and androgens production.
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
TLDR
It is suggested that cytochrome b5 plays a role in regulating the activities of P450c17 to optimize the balance between sex hormone synthesis and glucocorticoid synthesis, and in human testes which contains a high b5/P450 ratio, 17 alpha-hydroxyprogesterone can serve as an intermediate in testosterone production.
Two CYP17 genes in the South African Angora goat (Capra hircus) – the identification of three genotypes that differ in copy number and steroidogenic output
TLDR
This study clearly demonstrates the presence of two CYP17 genes in the South African Angora goat, and further implicates CYP 17 as the primary cause of the observed hypocortisolism in this subspecies.
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.
TLDR
Hormonally regulated serine phosphorylation of human P450c17 suggests a possible mechanism for human adrenarche and may be a unifying etiologic link between the hyperandrogenism and insulin resistance that characterize the polycystic ovary syndrome.
Regulation of 17,20 Lyase Activity by Cytochrome b5 and by Serine Phosphorylation of P450c17*
TLDR
Cytochrome b5 and phosphorylation enhance 17,20 lyase activity independently of each other, probably by increasing the interaction between P450c17 and NADPH-cytochrome P450 oxidoreductase.
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