Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.

@article{Tomlinson2001CortisolMA,
  title={Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.},
  author={J W Tomlinson and P. M. Stewart},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  year={2001},
  volume={15 1},
  pages={61-78}
}
Two isoforms of the enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) interconvert the active glucocorticoid, cortisol, and inactive cortisone. 11beta-HSD1 is believed to act in vivo predominantly as an oxo-reductase using NADP(H) as a cofactor to generate cortisol. In contrast, 11beta-HSD2 acts exclusively as an NAD-dependent dehydrogenase… CONTINUE READING