Cortisol is a suppressor of apoptosis in bovine corpus luteum.

  title={Cortisol is a suppressor of apoptosis in bovine corpus luteum.},
  author={Junichi Komiyama and Ryo Nishimura and Hwa-Yong Lee and Ryosuke Sakumoto and Masafumi Tetsuka and Tomas Javier Acosta and Dariusz Jan Skarzynski and Kiyoshi Okuda},
  journal={Biology of reproduction},
  volume={78 5},
Glucocorticoid (GC) acts as a modulator of physiological functions in several organs. In the present study, we examined whether GC suppresses luteolysis in bovine corpus luteum (CL). Cortisol (an active GC) reduced the mRNA expression of caspase 8 (CASP8) and caspase 3 (CASP3) and reduced the enzymatic activity of CASP3 and cell death induced by tumor necrosis factor (TNF) and interferon gamma (IFNG) in cultured bovine luteal cells. mRNAs and proteins of GC receptor (NR3C1), 11beta… CONTINUE READING
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